Effect Of Zomoshin-6 Decoction And Caragana Jubata (Pall.) On Haemostatic Parameters And Lipid Profiles In Diabetic Rats
- Author:
Dejidmaa B
1
;
Chimedragchaa Ch
1
;
Naran G
1
;
Dagvatseren B
1
;
Varlamova Ts
1
;
Sarantsetseg G
1
;
Khongorzul D
1
Author Information
1. Traditional Medical Science, Technology and Production Corporation of Mongolia
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Caragana jubata (Pall.);
zomoshin-6
- From:
Journal of Oriental Medicine
2012;3(2):27-28
- CountryMongolia
- Language:English
-
Abstract:
Introduction: Diabetes mellitus is a complex, progressive
disease, which is accompanied by multiple cardiovascular
complications. Oxidative stress is significantly increased in
diabetic patients and may lead to great haemostatic
disturbances existing in these patients. The major thrust was to
review current literature on potential interrelationships between
haemostatic and metabolic abnormalities in diabetes mellitus.
Zomoshin-6 decoction and Caragana jubata (Fabaceace) used
in traditional Mongolian medicine have been shown to have
haemostatic and antiviral effects.
Objectives: The aim of this study was to examine the effect of
Caragana jubata (Pall.) Poir. and Zomoshin-6 decoction on
haemostatic parameters and lipid profiles in diabetic rats.
Methods: Diabetes was induced in rats by using alloxan at a
dose of 150 mg/kg. Control group received distilled water.
Caragana jubata (Pall.) Poir and Zomoshin-6 were administered
orally at doses of 2.0 g/kg and 0.2 g/kg respectively. Aspirin
(100mg/kg) was used for comparison as a standard medicine.
All treatments were performed daily for 3 weeks. Blood samples
were obtained and analyzed for fibrinogen levels, prothrombin
time, triglycerides (TG) and plasma uric acid.
Results and conclusions: Levels of TG (p<0.05), glucose
(p<0.03) and plasma uric acid (p<0.02) were increased in rats
administered alloxan compare to control and these were
significantly reduced by Caragana jubata and Zomoshin-6
treatments (Table 1). Caragana jubata and Zomoshin-6
significantly reduced increases in fibrinogen (p<0.05) level and
prothrombin time induced by alloxan (Table 2).
Table 1. Effect of Caragana jubata (Pall.) Poir and Zomoshin-6
on alloxan-induced increase in levels in TG, uric acid, and
glucose.
Table 2. Effect of Caragana jubata (Pall.) Poir and Zomoshin-6
on levels of fibrinogen and prothrombin time in rats given alloxan
Parameters Control Alloxan 150 mg/kg
Alloxan 150 mg/kg Caragana jubata 2.0 g/kg Zomoshin-6 tan
0.2 g/kg Aspirin 100 mg/kg
Triglycerde ( mg/dl) 80.9±2.9 139.1±1.7 57±1.8* 64.0±2.5*
75±1.7* Uric acid (mg/dl)1.3±0.4 2.82±0.9 0.85±0.1* 0.9±0.2**
1.1±0.6* Glucose (mg/dl) 110.3±2.8 140±11 99.2±5***
135.5±22* 125.2±31*
Control Alloxan 150 mg/kg
Alloxan 150 mg/kg
Caragana jubata 2.0 g/kg Zomoshin-6 0.2 g/kg
Aspirin 100 mg/kg Fibrinogen (g/l)221.2±8.7 254±3.7 264.3±4.0*
207.4±3.5** 168.4±1.9** Prothrombin time (sec) 14.1±4.6
9.57±0.3* 22.7±2.3* 22.8±0.7** 20.5±3
