Effect Of Some Traditional Drug And External Therapies On Changes Of Tnf Levels
- Author:
Li Mandakh
1
;
Ambaga M
1
;
Tserendagva D
1
;
Oldokh S
1
Author Information
1. New Medicine Institute
- Publication Type:Journal Article
- Keywords:
TNF;
traditional treatment
- From:
Journal of Oriental Medicine
2012;3(2):24-24
- CountryMongolia
- Language:English
-
Abstract:
In this study, the effects of traditional drugs such as Zachun-13 and
Sampilnorov on serum levels of tumor necrosis factor (TNF) in mice
model of arthritis induced by formalin were examined. Moreover, the
effect of traditional external therapies including acupuncture,
cauterization, pricking-cupping and massage on serum TNF levels in
patients with spinal disk herniation and long-term back muscle
injury.
The study was done at the Research Center of Monos Medical
University. Arthritis was induced by formalin (0.5 g/kg) injection into
the phalangeal joints of mice. Sampilnorov and Zachun-13 were
administered daily through oral tube at concentration of 42.5 mg/kg
and 14 mg/kg respectively. Serum levels of TNF were determined 1,
3 and 7 days after initiating the treatment. Acupuncture,
cauterization, pricking-cupping and massage were applied to
patients once a day for 10 days.
After 1 day of treatment, serum levels of TNF was increased 3.09
fold by formalin administration compare to control. This increase
was reduced by Sampilnorov and Zachun-13 1.19 and 1.8 fold
respectively. Serum levels of TNF were increased 3.0 fold in mice
after 3 days of formalin administration. Sampilnorov and Zachun-13
reduced these increases 1.17 and 1.93 fold respectively.
Serum levels of TNF increased 15.2 fold in patients with spinal disk
herniation and long-term back muscle injury compare to normal
range of TNF level. Acupuncture, cauterization, pricking-cupping
and massage reduced increased serum levels of TNF in patients 1.3
fold.
These results indicate that traditional drugs Zachun-13 and
Sampilnorov and traditional external therapies including
acupuncture, cauterization, pricking-cupping and massage can be
effective for treatment of joint conditions by inhibiting TNF
production.
