Effect Of Shinar-8 On Collagen-Induced Rheumatoid Arthritis In Mice
- Author:
Badampagamdulam A
1
;
Ambaga M
1
;
Bayarmaa E
1
Author Information
1. Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
Collagen-induced rheumatoid arthritis;
shinar-8
- From:
Journal of Oriental Medicine
2012;3(2):23-23
- CountryMongolia
- Language:English
-
Abstract:
Background: Rheumatoid arthritis is a chronic inflammatory
disease that leads to the destruction of articular cartilage and
ankylosis of the joints. Traditional drug Shinar-8 is made from 8
components including Glycyrrhiza uralensis Fisch., Tribulus
terrestric, Iris tenuifolia, Thlaspi arvense, Ribes diacanthum
Pall., Ephedra Przewalskii Stapf., Rosa acicularis Lindl., and
Cynara scolymus L.
Objectives: The effect of Shinar-8 on mice rheumatoid arthritis
model induced by collagen was examined.
Methods and Materials: Laboratory tests and histopathological
analysis were carried out 35, 49, and 63 days after collagen
injection or 14, 28, and 42 days after Shinar-8 treatment.
Results and conclusions: LD50 of Shinar-8 was found to be
10.34g/kg. This was 41.36 fold higher than the treatment dose of
Shinar-8. Leukocytosis in peripheral blood was reduced by
Shinar-8 (41%). On 14 and 28 days after Shinar-8 treatment
signs of inflammation were disappeared although pannus and
erosion remained. Normal joint spaces, clear articular surface,
proliferation of chondrocytes, and hyperplasia were observed by
histological analysis after 42 days of Shinar-8 treatment. Shinar-
8 may have anti-inflammatory effects on collagen-induced
arthritis in mice.
