Effect Of Moxa At Guanyuan Acupoint On Qlq Of Chemotherapy Patients And Cx43 Expression Of The Cyclophosphamide Treated Mice Stomach
- Author:
Enkhtuya V
1
;
Sanduijav R
1
;
Chai Tie Qu
1
Author Information
1. School of Traditional Medicine, Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
Guanyuan acupoint;
chemotherapy
- From:
Journal of Oriental Medicine
2012;3(2):22-22
- CountryMongolia
- Language:English
-
Abstract:
Objective: To explore effects of using direct moxa at Guanyuan
acupoint in palliative care for cancer patients during the
chemotherapy
Methods: In single blind, randomized controlled clinical trial,
examined effects of using direct moxa at Guanyuan acupoint. 24
gastric cancer patients undergoing postoperative chemotherapy at
National Cancer Center of Mongolia were recruited and randomized
into 2 groups: control and intervention. The intervention consisted of
25 min direct moxa at Guanyuan acupoint once a day for 5 days.
The EORTC QoL 30 questionnaires were filled by the patients and
self-designed patient assessment questionnaire based on MD
Anderson Symptom Inventory were filled by blinded medical
personal, before and after the chemotherapy. Study was approved
by Ethical Committee of MOH of Mongolia.
Explored the relationship between moxa at Guanyuan acupoint and
Connexin 43 (Cx43) expression in the cyclophosphamide treated
mice stomach by IHC method.
Results: The QoL of post-operative gastric cancer patients before
chemotherapy were similar to EORTC reference value.
Chemotherapy will significantly decrease patients QoL especially
nausea & vomiting, appetite loss symptom scales. Moxa at
Guanyuan had significantly decreased fatigue score of the post-
operative chemotherapy gastric cancer patients (P<0.05) and
positively regulated Global Health score and other symptom scales
especially nausea & vomiting, appetite loss scores. During the
treatment no adverse effects of moxa treatment were observed.
IHC analysis of cyclophosphamide treated mice stomach reveals
Strong connexin 43 expresion in gastric crypt. Conclusion:
Guanyuan (CV 4) is Front-Mu Point of the Small Intestine, a
crossing point of Three Yin Meridians of Foot, Stomach meridian of
Foot Yang Ming and Conception Vessel. It is the one acupoint can
gather qi of many meridians, which has Yin within the yang
character and considered the physical center of gravity of the human
body and seat of one\'s internal energy. Therefore it could warm the
kidney to invigorate yang, tonify the Yuan- Primary qi, regulate
Thoroughfare and Conception Vessels, thus can cultivate yuan-
primary energy. Moxa is the non invasive treatment method of
acupuncture and moxa at Guanyuan can be broadly used in cancer
palliative care to reduce the side effects of chemotherapy and
improve quality of life of cancer patients.
