Effect Of Iris Ventricosa Pall On Ccl4-Induced Hepatic Injury In Rats
- Author:
Uranzaya D
1
;
Ariunaa Z
1
;
Uuganbayar B
1
;
Purevsuren G
1
Author Information
1. Traditional Medical Science Technology and Production Corporation of Mongolia
- Publication Type:Journal Article
- Keywords:
Iris ventricosa;
CCl4-induced liver injury;
inflammation
- From:
Journal of Oriental Medicine
2012;3(2):20-20
- CountryMongolia
- Language:English
-
Abstract:
Species of the genus Iris (Iridaceae) comprises more than 1500
species and 14 species are growing in Mongolia. These are
used in Mongolian traditional medicine espesially for treatment
of cancer and inflammation. Various biologically active
substances have been determined in genus Iris family of plants
such as flavones and isoflavones, peltogynoids (Irisoid A, B, C,
D and E), saponins, coumarins and benzoquinones. Iris
ventricosa is one of the genus Iris family plants.
The aim of the present study is to evaluate hepatoprotective
effects of Iris ventricosa on carbon tetrachloride (CCl4)-induced
liver injury in rats.
The underground part of Iris ventricosa Pall was collected in
September, 2011 in the botanical garden of Botanical Institute of
Mongolia. Serum levels of aspartate aminetransferase, alanine
aminetransferase, and alkaline phosphatase were determined.
Histological study was also carried out. Aqueous and spirituous
extracts (100 mg/kg) of Iris ventricosa significantly reduced
levels of aspartate aminetransferase, alanine aminetransferase,
and alkaline phosphatase in rats administered CCL4.
Histopathological examination revealed that CCL4-induced
changes in the liver were ameliorated by Iris ventricosa
treatment.
This is the first study that has shown the hepatoprotective effect
of Iris ventricosa Pall in rats administered CCL4. The
hepatoprotective effect of Iris ventricosa can be related to its
potent antioxidative and anti-inflammatory activities. Neutralizing
reactive oxygen species by nonenzymatic mechanisms and
enhancing the activities of natural antioxidant enzymes of the
liver may be the main mechanisms of the hepatoprotective effect
of Iris ventricosa on CCl4-induced liver injury in rats.
