Effect Of Deva-5 On Bacterial Growth In Vitro
- Author:
Oyuntsetseg N
1
;
Oyunbileg J
1
;
Chimedragchaa Ch
1
;
Oldokh S
1
;
Munkh-Undrakh N
1
Author Information
1. School of Traditional Medicine, Health Sciences University of Mongoliaa Public
- Publication Type:Journal Article
- Keywords:
Deva-5
- From:
Journal of Oriental Medicine
2012;3(2):19-19
- CountryMongolia
- Language:English
-
Abstract:
Traditional medicine describes common flu as excess of blood and
bile heat combined with microbes which results infectious heat.
Deva-5 is a decoction used which treats infectious heat. The aim of
this study is to analyze components of Deva-5 decoction by
traditional methods. Deva-5 is composed of Gentiana decumbens
L., Terminalia Chebula Retz., Polygonium bistorta L., Momordica
cochinchinensis (Lour) and Chiazospermum erectum Bernh. It has a
cool power and dispels infectious heat and kills microbes. The main
component of the decoction is Gentiana decumbens L. It has a
sweat taste and clears heat, kills microbes, and cures typhus.
The effects of water extract of Deva-5 on pathogenic bacteria
including Streptococcus pneumonia, Staphylococus aureus, and
Escherichia coli were examined. Plates of bacteria treated with
Deva-5 at 6 different concentrations (1 -30 %) were incubated at
37°C for 24 h and then the diameter of the circle of bacterial growth
was measured. Amoxicillin, nistatin, flukanosol, and ciprofloxacin
were used as comparison. Acute and chronic toxicities of Deva-5
were determined in mice. Deva-5 was given orally to mice at doses
of 200 mg/kg and 500 mg/kg for 28 days. In addition, therapeutic
dose of Deva-5 was also determined in mice.
Deva-5 inhibited growths of Streptococcus pneumonia and
Staphylococus aureus at concentrations of 5 %, 10 %, 20 %, and 30
%. Deva-5 more effectively inhibited growth of Streptococcus
pneumonia than that of Staphylococus aureus. Growth of
Escherichia coli was not inhibited by Deva-5 treatment. The median
lethal dose of (LD50) of Deva-5 was 6.89 g/kg. There were no
difference between the control and Deva-5-treated groups in
movements, hair color, food consumption, and the number of
offspring of mice. No histopathological changes were observed in
solid organs of animals treated with Deva-5. Therapeutic doses of
Deva-5 were found to be 50-150 mg/kg. These results suggest that
Deva-5 has antibacterial effects in vitro and it is safe in mice.
