Effect Of Calcite On Osteoporosis Model Of Rats Induced By Retinoic Acid
- Author:
Tsendjav D
1
;
Seesregdorj S
1
;
Munkhtulga L
1
;
Han Zhi-qiang
;
Author Information
1. School of Traditional Medicine, Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
retinoic acid;
calcite
- From:
Journal of Oriental Medicine
2012;3(2):18-18
- CountryMongolia
- Language:English
-
Abstract:
Objective: In this study, the effect of water solution of calcite on
changes of behavior, body and organ weight, and bone
thickness in rat model of osteoporosis induced by retinoic acid
was examined.
Methods: Retinoic acid was administered to rats at
concentrations of 70 mg/kg for 14 days. Induction of
osteoporosis was evaluated by histological analysis. Once
osteoporosis had developed, calcite and Calci D-D were given to
rats with foods for 30 days.
Results: After induction of osteoporosis, mucosal membranes of
rats got erosive, fur was curled up and lusterless, paws and nails
were broken down. Animal get pretty tired with poor appetite. No
significant differences were observed in weights of internal
organs between the groups.
Body weight was reduced (197±8.14 g) in rats administered with
retinoic acid. Femoral bone weight (0.6459±0.07 g) and
thickness was (3.02±0.02 mm) also reduced by retinoic acid.
Calcite significantly increased body weight (210±6.04 g), femoral
bone weight (0.8219±0.1g) and bone thickness (4.3±0.8 mm) in
rat model of osteoporosis. Body weight (0.6463±0.13 g), femoral
bone weight (0.6463±0.13 g) and bone thickness (3.6±0.16 mm)
were also increased by Calci D-Denk treatment.
Conclusion: These results suggest that calcite can be a
potentially effective agent for treatment of osteoporosis.
