Hypoglycaemic Effect Of Antidiabet-3 Preparation In Alloxan-Induced Diabetic Rabbits
- VernacularTitle:Туулайд Аллоксанаар Чихрийн Шижин "Өвчний Эмгэг Загвар Үүсгэсэн Үед Антидиабет-3 Бэлдмэлийн Цусан Дахь Глюкоз Бууруулах Үйлдлийг Судалсан Дүн
- Author:
Batgerel L
1
;
Ambaga M
1
;
Saranchimeg B
1
;
Tsend-Ayush D
1
Author Information
1. Health Sciences University Of Mongolia
- Publication Type:Journal Article
- Keywords:
Alloksan;
glucose;
artichoke;
sugar diahetes illness disease
- From:
Journal of Oriental Medicine
2012;2(1):51-55
- CountryMongolia
- Language:Mongolian
-
Abstract:
Preparation of the water Extract from Antidiabet-31:10 was suspended in distilled water (100 mL) and allowed to stand at 4◦C. It was then filtered through several layers of muslin cloth and filtrate (water extract) was discarded Male Shinshila rabbits, weighing 1.5–2.7 kg, were rendered diabetic with an injection of 100 mg/kg alloxan monohydrate into a marginal ear vein. To reduce risk of nephrotoxicity from hyperuricemia, a 7 ml/kg body wt intravenous injection of 0.9% saline was given immediately after the injection ofalloxan. To counteract initial hypoglycemia, 3.5– 4.0 g glucose/kg body wt was given subcutaneously [27.5% (wt/vol) solution] 5– 6 h after the injection of alloxan. Diabetes was defined by a blood glucose concentration 16.9 mmol/l on 1 day. The total number of rabbits used was 28. Plasma was obtained by centrifugation of blood glucose, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol,triglycerides (TG), ‘’Humylazer 2000’’ chemistry analyzers automated (Human, Germany). As shown in Table 1, showed significant antihyperglycemic activity (p<0.05). Antidiabet-3 (AD3) and control failed to achieve euglycemia but caused a significant (p< 0.05) reduction in glucose levels compared to their initials values. The result of the experiment were confirmed that using by blood glucose in antidiabet-3 treatment groups taken for an observation at 3 dayfrom it was decreased to 22.20±2.5 (2.88%), post 7 day it was decreased 19.03±2.75 (14.3%), post 14 day it was 14.86±0.80 (33.06%), which it is showed may increase the blood glucose from diabetic rabbits.
