Study Of The Hepatoprotective Actions Preparation On Lonicera Altaica Pall
- VernacularTitle:Алтайн Далан Хальс /Lonicera Altaica Pall/-Ны Элэг Хамгаалах Үйлдлийн Судалгаа
- Author:
Uuganbayar B
1
;
Ariunaa Z
1
;
Dagvatseren B
1
Author Information
1. Traditional Medical Science, Technology and Production Corporation
- Publication Type:Journal Article
- Keywords:
Lonicera Altaica;
alanine aminotransferase;
aspartate aminotransferase;
alkaline phosphatase
- From:
Journal of Oriental Medicine
2011;1(1):98-100
- CountryMongolia
- Language:Mongolian
-
Abstract:
In Mongolia, V.I.Grubov has described four species of Lonicera (Caprifoliaceae). Their habitats are mountain areas, borders of forests, mixed forests, and areas under rocky places, mainly in Khubsugul,
Khangai Khentei, Khobdo, Mongolian Altai, and Depression of Great Lakes, Mongol Daguur and the Gobi-Altai (Three beauty of Gobi) region of the country. The Tibetan medicine named berry Phan-ma’i bra’i bu (fruit seeds of Lonicera) was used for vitality and energy supplier. In some medical texts, the berry was described to be used for longevity. The fruits of Lonicera Altaica Pall is very advanced for fruit growing, since bred varieties have tasteful fruits, that ripe by end of May and there are many valuable vitamins, mineral and biological active substances in their fruits. Lonicera Altaica in /consumed traditional people/ Mongolian Traditional medicine is reputed for its treating liver, stomach and cardiac disorders, moreover, it is known for rejuvenation action. Objective: This study aims to investigate one of the species preparation from Lonicera Altaica’s of general, specific and expressing pharmacological experiments. We were preparad decocted extract from fruits of the Lonicera Altaica by 1:10, was obtained to the experimental animals intraperitonial injected by in a dose of 50, 100, 150 mg/kg. We induced experimentel models in total of 124 wistar rats and 168 white mice in next ways: preparation of Lonicera Altaica Pall’ LD50, antiimflammatory, diuretic effect, biliary excretion properties, detoxifying function and the hepatoprotective effect preparation models on liver inflammation and fibrosis induced by carbon tetrachloride (CCl4 ). We studied biochemical and hystophatological
examination. Methods: In this study, the protective effect preparation from Lonicera Altaica on liver inflammation and fibrosis induced by carbon tetrachloride (CCl4 ). We examined the inhibitory mechanism preparation of Lonicera Altaica on CCl4-induced hepatic cirrhosis in rats. At 4, 8, and 12 wk, liver tissues were examined histopathologically for fibrotic changes produced by preparation treatment. In the histopathological study we carried out liver tissues from each rat were dissected; fixed in 10 % neutral-buffered formalin. Microscopic examination was conducted on 4 µm thick H. & E. stained sections from paraffin embedded specimens. Results: From the result of the study it was determined the preparation Lonicera Altaica Pall. has no toxicity. This preparation has anti inflammatory, diuretic activity and comparing with the control group. In this study, the protective effect preparation from Lonicera Altaica on liver inflammation and fibrosis induced by carbon tetrachloride (CCl4 ) has been investigated in rats. Preparation from Lonicera Altaica significantly suppressed CCI4 -induced hepatic necrosis and inflammation, as determined by the serum enzymatic activities of alanine and aspartate aminotransferase and serum alkaline phosphatase levels. Conclusion: Treatment with preparation from Lonicera Altaica attenuated the necro-inflammation and fibrogenesis in the CCI4 -induced hepatic fibrosis, and thus it effective as a anti imflammatory and antifibrotic agent.
