Protecting the Stomach of a Tamed Dragon by Feeding A Case Study
- VernacularTitle:Шимжүүлэх Аргаар Номхотгосон Жоншны Ходоод Хамгаалах Үйлдлийн Судалгаа
- Author:
Soyolt T
1
;
Seesregdorj S
1
Author Information
1. Health Sciences University Of Mongolia
- Publication Type:Journal Article
- Keywords:
Gastric ulcer;
calcite;
traditional medicine
- From:
Journal of Oriental Medicine
2011;1(1):89-91
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction an Ulcer is defined as disruption of the mucosal integrity of the stomach and/or duodenum and is associated with increased risk factor for stomach and pancreatic cancer. Gastric ulcer incidence is increasing among young adults worldwide. Disability resulting from gastric ulcer is not declined. Due to the traditional Mongolian disease classification, gastric ulcer is equivalent to gastric ‘bor’. Stone-based medicines are widely used in Mongolian traditional medicine. Mineralbased medicines are safe to store and transport and there are relatively big sources of minerals comparing to animal and plant-
originated raw materials. Calcite is the most widely used mineral among other stone-based medicines. Chronic diseases such as gastric ‘bor’ are treated by calcite containing medicines in Traditional Mongolian Medicine. Objectives In this study we examined the effect of calcite on animal model of gastric ulcer using biochemical analysis. Materials and methods All experiments were accomplished in the laboratory of the Scientific and Technological Corporation of Traditional Medicine according to the permission of Biomedical Ethics Review Committee of Ministry of Health. We used male calcite found in the cave named ‘Tsagaan agui’ which is located in the territory of ‘Bayanlig’ soum of ‘Bayanhongor’ province. In Traditional Mongolian Medicine, two different methods of drug subduing (detoxification and improving its delivery and effectiveness) are used; rich and strong. In this study, we subdued calcite
by using both methods and the effect of rich subdued calcite was examined on acetic acid-induced gastric ulcer in experimental animal models. Strong subdued calcite was used for only determining its mineral compositions. Thirty healthy mice (body weight 23-40 g) and 30 Wistar rats (body weight 200-300 g) were used for the study. Average lethal dose of calcite was examined by the V. P. Prosorovsky’s express method (1978) and evaluated according to the classification of K. K. Sydorov (1987). Mineralogical study on calcite was performed by X-Ray Fluorescence Element Analyzer MESA-500W-HORIBA (MNS JIS K 0119:2003). Gastric ulcer was developed by acetic acid by the method of S. Okabe and J. Koth (1971). Healing process of the gastric ulcer was monitored by histochemical analysis. Results Calcite had turned bright yellow with bitter, strong and sour taste after the rich subduing. Moreover it became softer and changed its shape to small crystals without sharp ends and
obtained dissolving property in water. According to the classification of Sydorov, average lethal dose of rich subdued calcite was 14.6 g/ kg suggesting that calcite exerts minimal toxic effects. Mineral examination results showed that some toxic elements such as Si, P, F, Mn, Al, and S were reduced in both calcites. Compositions of Na, Mg, and Ê were increased in rich subdued calcite. Compositions of Na, Mg, K, and Fe were decreased and Ca composition was increased in strong subdued calcite.
Rich subdued calcite at concentration of 1 g/kg had anti-inflammatory effects reducing vascular permeability and improving blood circulation. Histological analysis showed that acetic acid-induced gastric ulcer begun to heal at 7th days after the calcite administration. Proliferation was determined at 14th days and the ulcer was completely disappeared at 21st days after the calcite administration. Conclusions
1. Calcite became softer and water soluble after rich subduing.
2. Calcite has minimal toxic effects according to Sydorov’s classification.
3. Mineral examination results showed that compositions of essential elements were increased and compositions of possible toxic elements were reduced in both subdued calcites.
4. Rich subdued calcite had anti-inflammatory effects reducing vascular permeability and improving blood circulation.
5. Acetic acid-induced gastric ulcer was treated by calcite within 21 days suggesting that calcite speeds up gastric ulcer healing.
