The Study Of Hepatoprotective And Choleretic Actions Of Saxifraga Hirculus L
- VernacularTitle:“Ямаан Сэрдэг” /Saxifraga Hirculus L. / Ургамлын Элэг Хамгаалах, Цөс Хөөх Үйлдлийн Судалгаа
- Author:
Khishigjargal S
1
;
Sarantsetseg B
1
;
Tumurbaatar N
1
;
Zorigt T
1
Author Information
1. Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
Experimental pathological model of toxic (CCl4 );
drug-induced (TG) hepatitis;
bile acid detergent action;
Saxifraga hirculus L
- From:
Journal of Oriental Medicine
2011;1(1):73-77
- CountryMongolia
- Language:Mongolian
-
Abstract:
Considering the fact that it is becoming important to broaden the studies of herbal medicine with few side effects which can treat acute and chronic inflammations of the liver and biliary tract, liver cirrhosis and can prevent from transformation into cancer, we chose Saxifraga hirculus L as our study objective which has been used in liver and biliary disease treatments of Tibetan – Mongolian traditional medicine for many years. This study aims to study one of the species of the family Saxifrgaceaca, Saxifraga hirculus L’s liverprotective activity and effect on the liver and biliary tract diseases resulted from bile stasis, which frequently comes as an ingredient of compound prescription of the traditional medicine.
01/01 Study methods: Experimental pathological liver disease model was developed in total of 520 white rats and 80 white mice in 2 ways, Saxifraga hirculus L’s bile-forming and detoxifying function and effects on the detergent effect of bile, necrotic liver cell lysis and stability of lung cell surfactant were compared with the standard drugs such as Legalon and Cholasos and double proven by biochemical, pathohistologi and histochemical studies. 70% alcohol extract was prepared from the selected Saxifraga hirculus L, and dried and decocted extract was obtained from this and given to the experimental animals by oral intragastric tube in a dose of 100mg/kg. As the result of pathohistologi and histochemical study, necrosis and necrobiosis of liver cells were dominantly observed in CCl4 induced “toxic inflammation”, cholestatic syndrome and dysfunction of detoxication action were observed in Tetracycline Hydrochlorideinduced(druginduced)toxic inflammation in the experimental animals. The Saxifraga hirculus L’s most potent dose to treat and protect liver was estimated as 100mg/kg and this was 31 times lower than its LD50. In our study,Saxifraga hirculus L has possessed an anti-inflammatory effect on each stages of inflammation which is alteration, exudation and proliferation. In other hand, Saxifraga hirculus L increased the biliary secretion and excretion speed, protected from toxic detergent effect of bile acid, improved detoxication effect of the liver, protected from the necrotic cell lysis, showed an antioxidant and membrane stabilizing activity and these actions were compared with the standard medicines such as Legalon and Cholasos which in some cases, above mentioned effects were higher than these drugs. The hepatoprotective action of Saxifraga hirculus L may have been related to its contents such as compound flavonoids of the quercetin group,
aglycone and bitter hyperoside. Also in the case of drug induced toxic hepatitis, Saxifraga hirculus L increased the amount of glycogen and nuclear DNA in the liver tissue by 22-24.5% compared to the control group and was proven by histochemical study.
