Inflammaging: Molecular Pathways and Implications in Oral Pathology
10.5856/JKDS.2024.17.4.174
- Author:
Sang Hee LYOO
1
;
Ki Woo KIM
Author Information
1. Division of Physiology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea
- Publication Type:REVIEW ARTICLE
- From:Journal of Korean Dental Science
2024;17(4):174-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
Inflammaging is known to be an aging-associated chronic, low-grade inflammatory state that significantly influences the pathophysiology of various age-related diseases, including those affecting oral health. This review explores the molecular and cellular mechanisms of inflammaging and its implications in oral pathology. We will review key factors contributing to inflammaging, including cellular senescence, and immune dysregulation, all of which induce pro-inflammatory cytokines and reactive oxygen species (ROS). These inflammatory mediators affect oral tissues, predisposing individuals to chronic conditions such as periodontitis, and dental pulp inflammation. Additionally, we will briefly discuss how the oral microbiome is involved in the regulation of inflammaging. Understanding the molecular pathways of inflammaging may provide valuable insights not only into oral health but also into potential health strategies for the aging population.
