Effect of Superior Cervical Sympathetic Ganglion Block on Brain Injury Induced by Focal Cerebral Ischemia/Reperfusion in a Rat Model.
- Author:
Ae Ryoung LEE
1
;
Mi Ok YOON
;
Hyun Hae KIM
;
Jae Moon CHOI
;
Hae Yuong JEON
;
Jin Woo SHIN
;
Jeong Gill LEEM
Author Information
- Publication Type:Original Article
- Keywords: cerebral ischemia/reperfusion injury; local anesthetics; sympathetic ganglion block
- MeSH: Anesthetics, Local; Animals; Blood Vessels; Brain Injuries*; Brain*; DNA; Edema; Ganglia, Sympathetic*; Humans; Lidocaine; Male; Middle Cerebral Artery; Models, Animal*; Rats*; Rats, Sprague-Dawley; Superior Cervical Ganglion; Vascular Diseases
- From:The Korean Journal of Pain 2007;20(2):83-91
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: Cerebral blood vessels are innervated by sympathetic nerves that originate in the superior cervical ganglia (SCG). This study was conducted to determine the effect of an SCG block on brain injury caused by focal cerebral ischemia/reperfusion in a rat model. METHODS: Male Sprague-Dawley rats (270-320 g) were randomly assigned to one of three groups (lidocaine, ropivacaine, and control). After brain injury induced by middle cerebral artery (MCA) occlusion/reperfusion, the animals were administered an SCG bloc that consisted of 30 microliter of 2% lidocaine or 0.75% ropivacaine, with the exception of animals in the control group, which received no treatment. Twenty four hours after brain injury was induced, neurologic scores were assessed and brain samples were collected. The infarct and edema ratios were measured, and DNA fragmented cells were counted in the frontoparietal cortex and the caudoputamen. RESULTS: No significant differences in neurologic scores or edema ratios were observed among the three groups. However, the infarct ratio was significantly lower in the ropivacaine group than in the control group (P<0.05), and the number of necrotic cells in the caudoputamen of the ropivacaine group was significantly lower than in the control group (P<0.01). Additionally, the number of necrotic and apoptotic cells in theropivacaine group were significantly lower than inthe control group in both the caudoputamen and the frontoparietal cortex (P<0.05). CONCLUSIONS: Brain injury induced by focal cerebral ischemia/reperfusion was reduced by an SCG block using local anesthetics. This finding suggests that a cervical sympathetic block could be considered as another treatment option for the treatment of cerebral vascular diseases.
