Purine Nucleoside Phosphorylase Activities in Sera and Lymphocytes of Peripheral Blood from Patients with Allergic Contact Dermatitis and Drug Eruption.
- Author:
Mie Soon PARK
;
Inn Ki CHUN
;
Young Pio KIM
- Publication Type:Original Article
- Keywords:
Purine nucleoside phosphorylase;
Allergic contact dermatitis;
Drug eruption
- MeSH:
Dermatitis, Allergic Contact*;
Dermatitis, Contact;
Drug Eruptions*;
Humans;
Lymphocytes*;
Purine-Nucleoside Phosphorylase*
- From:Korean Journal of Dermatology
1988;26(2):160-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was designed to measure the activity of purine nucleosiae phosphorylase(PNPase) in sera and lymphocytes af peripheral blood from patients with allergie contact dermstitis and drug eruption since PNPase activities are known to be decreased in cell-mediated immune deficieney diseases. The PNPase activities in sera and lymphocytes of normal subjects were (7.2 +1.05) * 105 unit/L of sera and (1.85+0.38) unit/102 lymphocytes, respectively. In allergic contact dermatitis, the PNPase activities in sera and lymphocytes of patients were (3.9+0.78) *105 unit/L of aera and (0.69+0.23) uoit/102 lymphocyteis, which were signifieantly lower than those of normal subjects. There were no differences in PNPase activities of sera and lymphocytes between drug eruption patients and normal subjects. From these results, it is suggested that the lowered PNPase aetivity in allergie contact dermatitis might be associated with abnormal lymphocytes differentiation or activation or some other unknown mechanism, since lowered PNPase activity in allergic contact dermatitis is in contrast to the generally accepted concept that enhanced status of CMI in ACD will lead to the increase in PWPase activity.
