Sentinel Safety Monitoring System for Adverse Events of Special Interest Associated With Non-NIP Vaccines in Korea
10.3346/jkms.2025.40.e152
- Author:
Hakjun HYUN
1
;
Jung Yeon HEO
;
Yu Jung CHOI
;
Eliel NHAM
;
Jin Gu YOON
;
Ji Yun NOH
;
Joon Young SONG
;
Woo Joo KIM
;
Won Suk CHOI
;
Min Joo CHOI
;
Yu Bin SEO
;
Jacob LEE
;
Hee Jin CHEONG
Author Information
1. Department of Infectious Diseases, Ajou University School of Medicine, Suwon, Korea
- Publication Type:Brief Communication
- From:Journal of Korean Medical Science
2025;40(16):e152-
- CountryRepublic of Korea
- Language:English
-
Abstract:
South Korea’s current vaccination policies leave a surveillance gap for non-National Immunization Program (NIP) vaccines. In this study, we proposed a sentinel surveillance approach for monitoring the safety of non-NIP vaccines. Vaccination data were collected retrospectively among patients hospitalized with pre-defined adverse events of special interest (AESI) by reviewing electronic medical records in five university hospitals. This approach incorporates expert assessment to determine the causal relationship. We confirmed that 16 patients had received non-NIP vaccines among 860 patients diagnosed with AESI.We concluded one case of preeclampsia was possibly related to tetanus-diphtheria-pertussis vaccination. We propose a multi-hospital-based, retrospective assessment system for predefined AESIs as an alternative to active vaccine safety monitoring method. These efforts are expected to enhance both the accuracy and timeliness of safety monitoring in South Korea.
