Impact of Early Enteral Nutrition on In-Hospital Mortality in Patients with Hypertensive Intracerebral Hemorrhage.
10.3340/jkns.2010.48.2.99
- Author:
Jeong Shik LEE
1
;
Cheol Su JWA
;
Hyeong Joong YI
;
Hyoung Joon CHUN
Author Information
1. Department of Neurosurgery, National Medical Center, Seoul, Korea. chsjwa@hanmail.net
- Publication Type:Original Article
- Keywords:
Enteral nutrition;
Intracerebral hemorrhage;
Mortality
- MeSH:
Body Weight;
C-Reactive Protein;
Cerebral Hemorrhage;
Enteral Nutrition;
Glasgow Coma Scale;
Hospital Mortality;
Humans;
Incidence;
Intensive Care Units;
Intracranial Hemorrhage, Hypertensive;
Multivariate Analysis;
Pneumonia;
Retrospective Studies;
Serum Albumin
- From:Journal of Korean Neurosurgical Society
2010;48(2):99-104
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We conducted this study to evaluate the clinical impact of early enteral nutrition (EN) on in-hospital mortality and outcome in patients with critical hypertensive intracerebral hemorrhage (ICH). METHODS: We retrospectively analyzed 123 ICH patients with Glasgow Coma Scale (GCS) score of 3-12. We divided the subjects into two groups : early EN group (< 48 hours, n = 89) and delayed EN group (> or = 48 hours, n = 34). Body weight, total intake and output, serum albumin, C-reactive protein, infectious complications, morbidity at discharge and in-hospital mortality were compared with statistical analysis. RESULTS: The incidence of nosocomial pneumonia and length of intensive care unit stay were significantly lower in the early EN group than in the delayed EN group (p < 0.05). In-hospital mortality was less in the early EN group than in the delayed EN group (10.1% vs. 35.3%, respectively; p = 0.001). By multivariate analysis, early EN [odds ratio (OR) 0.229, 95% CI : 0.066-0.793], nosocomial pneumonia (OR = 5.381, 95% CI : 1.621-17.865) and initial GCS score (OR = 1.482 95% CI : 1.160-1.893) were independent predictors of in-hospital mortality in patients with critical hypertensive ICH. CONCLUSION: These findings indicate that early EN is an important predictor of outcome in patients with critical hypertensive ICH.
