Immunoglobulin G4-Related Disease in the Diaphragm:A Case Report

Author: Jin Woo KIM ¹ ; Taehwa KIM ; Kun-Il KIM ; Yeon Joo JEONG ; Dohyung KIM ; Dong Hoon SHIN ; Yun Seong KIM
Author Information

1. Departments of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
Publication Type:Case Report
From: Journal of the Korean Society of Radiology 2024;85(5):954-959
CountryRepublic of Korea
Language:English
Abstract: Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition characterized by mass-forming inflammation with a sclerosing pattern that can affect nearly any organ. However, involvement of the diaphragm in IgG4-RD is exceptionally rare. We present the case of a 62-year-old male patient with chest radiographic abnormalities. Further investigation with CT revealed an infiltrative mass in the right hemidiaphragm. This mass, composed of engorged feeding vessels, an atypical manifestation of IgG4-RD, was also associated with lymphadenopathy. Surgical excision confirmed the presence of IgG4-positive cell infiltration, solidifying the diagnosis of IgG4-RD. Notably, the patient remained asymptomatic and did not require any treatment postoperatively. This case highlights the uncommon presentation of IgG4-RD as an infiltrative diaphragmatic mass.