Growth differentiation factor 15: a promising biomarker in oral cancer
10.5125/jkaoms.2025.51.2.123
- Author:
Hyun Jun OH
1
;
Jong-Ho LEE
;
Soung Min KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
- Publication Type:BRIEF COMMUNICATION
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2025;51(2):123-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, withimplications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.
