Sensitization to component antigens in acute idiopathic urticaria in children.
10.4168/aard.2017.5.6.331
- Author:
Young Jin CHOI
1
;
Jung Min YOON
;
Yeo Soon CHANG
;
Jae Won OH
Author Information
1. Department of Pediatrics, Hanyang University Guri Hospital, Guri, Korea. jaewonoh@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Urticaria;
Allergen;
Diagnosis
- MeSH:
Allergens;
Alnus;
Arachis;
Artemisia;
Betula;
Child*;
Corylus;
Diagnosis;
Humans;
Immunoglobulin E;
Profilins;
Prunus persica;
Urticaria*
- From:Allergy, Asthma & Respiratory Disease
2017;5(6):331-335
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD). METHODS: We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP). RESULTS: Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10–40.59), 6 to rConr a 1 for hazelnut (1.53–11.97), 4 to rPru p 1 for peach (1.32–11.83). 6 to rAra h 8 for peanut (1.20–8.12), 6 to nAct d 8 for kiwi (0.85–3.32), 4 to rBet v 1 for birch (2.49–54.28), and 3 to rAln g 1 for alder (2.32–5.74). Six children were positive to nPru p 3 for peach (1.45–18.77), 4 to rCor a 8 for hazelnut (2.56–9.19), 2 to nArt v 3 for mugwort (3.40–7.42), and 3 to rBet v2 to profilin of birch (2.56–17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3). CONCLUSION: IgE sensitization to PR-10 or nsLTP may be allergen components for AIU in childhood.
