Hematological changes during the aggressive treatment of chronic myeloid leukemia (CML) in the chronic duration by hydroxyurea
- Author:
Thanh Ha Nguyen
- Publication Type:Journal Article
- Keywords:
leukemia
- MeSH:
Leukemia;
Hydroxyurea;
therapeutics
- From:Journal of Vietnamese Medicine
2001;15(2):47-51
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The aim of this study is to examine the effectiveness of hydroxyurea in treating CML patients in chronic phase. The result of the research shows that the induction treatment with hydroxyurea with initial dose of 40-60mg/kg body weight daily radically improves hematological condition for CML patients in chronic phase. All patients (42 patients) reached hematological remission (33.3% patients reached complete remission), 66.7% patients reached partial remission WBC decrease from 193.9117.7 g/l to 10.16.0 g/l. Percentage of myeloblast, promyelocyte, myelocyte and metamyelocyte in peripheral blood decrease from 35.08.0% to 6.96.6%. Hemoglobin concentration increase from 86.119.0 g/l to 96.013.3 g/l, RBC increase from 2.90.7 T/l to 3.20.5 T/l. The follow up during the time of induction treatment shows that main hematological indicators have changed gradually when approaching normal physiological values
