The clinical efficacy and cost-effectiveness of Lamellar body count in fetal lung maturation test.
- Author:
Seung Pyo HONG
1
;
Eun Kyung PARK
;
Sun Young JEONG
;
Ha Kyong JOO
;
Jee Hyun LEE
;
Hee Bong MOON
;
Young Me KOH
;
Jong Chul SHIN
;
Chang Yi KIM
Author Information
1. Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Lamellar body count;
fetal lung maturity;
Respiratory distress syndrome
- MeSH:
Amniocentesis;
Amniotic Fluid;
Apgar Score;
Female;
Gestational Age;
Humans;
Incidence;
Lung*;
Meconium;
Pregnancy, High-Risk
- From:Korean Journal of Obstetrics and Gynecology
2002;45(11):1951-1955
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the availability and efficacy of the Lamellar body count as a predictor of fetal lung maturity METHODS: Amniocentesis was performed for evaluation of fetal lung maturity status within 72 hours of delivery in 32 patients. A Lamellar body count in clean amniotic fluid (AF) was analyzed right after amniocentesis. In case of contaminated AF with meconium or blood, samples was centrifuged for 3 minutes and divided into three. The average of three samples was analyzed successively from Coulter counter. RESULTS: The incidence of RDS showed significant relation with gestational age, 1-minute and 5-minute Apgar Score. Using a value greater than 30,000/ l to indicate pulmonary maturity, the Lamellar body count predicted all lung-maturated cases with no false-negative results (100% negative predictive value). All 4 cases of RDS demonstrated Lamellar body count less than 30,000/microl. By using a lower cutoff of 10,000/microl to predict pulmonary immaturity. Positive predictive value was 100% in RDS patients. CONCLUSION: In high risk pregnancy, fetal lung maturity test from amniotic fluid lamellar body count is a rapid, simple and reliable method in making a decision of delivery-time. And also it has universal availability with cost-effectiveness when we consider the reality of korean medical situation
