A case of pancreatic intraepithelial neoplasm (PanIN-III) manifesting as recurrent pancreatitis.
- Author:
Byeong Seok SOHN
1
;
Sung Koo LEE
;
Myung Hwan KIM
;
Dong Wan SEO
;
Sang Soo LEE
;
Song Cheol KIM
;
Sae Jin JANG
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sklee@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Chronic pancreatitis;
Focal fibrosis;
PanIN;
Recurrent pancreatitis
- MeSH:
Acinar Cells;
Biopsy, Fine-Needle;
Carcinoma in Situ;
Cholangiopancreatography, Magnetic Resonance;
Female;
Fibrosis;
Humans;
Lymph Node Excision;
Pancreas;
Pancreatectomy;
Pancreatic Ducts;
Pancreatic Neoplasms;
Pancreatitis;
Pancreatitis, Chronic;
Splenectomy
- From:Korean Journal of Medicine
2008;74(3):310-314
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute recurrent pancreatitis has a variety of etiologies. We experienced a case of a tumor-forming pancreatitis in a 49 year old Korean woman who also had pancreatic intraepithelial neoplasm III (PanIN-III), and this manifested just like recurrent pancreatitis. She had a history of recurrent pancreatitis. She was found to have an early stage of pancreatic cancer via computed tomography and magnetic resonance cholangiopancreatography. EUS guided fine needle aspiration (FNA) showed only many acinar cells of the pancreas. But due to the possibility of her having pancreatic carcinoma, she underwent distal pancreatectomy and splenectomy with lymph node dissection. Pathologically, the tumor of the pancreatic body showed secondary changes with focal fibrosis from the localized chronic pancreatitis. PanIN-III was observed in the pancreatic duct within the tumor, and there were no cancerous findings in the 13 dissected lymph nodes.
