Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle.
10.4142/jvs.2017.18.4.555
- Author:
Jaeyong SONG
1
;
Yongsun KIM
;
Oh Kyeong KWEON
;
Byung Jae KANG
Author Information
1. Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea. bjkang@kangwon.ac.kr
- Publication Type:Case Report
- Keywords:
adipose-derived mesenchymal stromal cells;
bone morphogenetic protein 7;
dogs;
ununited fractures
- MeSH:
Animals;
Bone Morphogenetic Protein 7;
Bone Regeneration;
Child;
Dogs;
Fractures, Ununited;
Gangwon-do;
Hospitals, Animal;
Humans;
Play and Playthings*;
Radius;
Ulna
- From:Journal of Veterinary Science
2017;18(4):555-558
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.
