Association of SNAP-25 Gene Ddel and Mnll Polymorphisms with Adult Attention Deficit Hyperactivity Disorder.
- Author:
Hasan HERKEN
1
;
Mehmet Emin ERDAL
;
Ayse Nur Inci KENAR
;
Gonca Ayse UNAL
;
Burcu CAKALOZ
;
Mustafa Ertan AY
;
Erinc YUCEL
;
Tuba EDGUNLU
;
Cem SENGUL
Author Information
- Publication Type:Original Article
- Keywords: ADHD; SNAP-25 gene; Genetic
- MeSH: Adult*; Attention Deficit Disorder with Hyperactivity*; Cell Membrane; Diagnostic and Statistical Manual of Mental Disorders; Genotype; Humans; Mass Screening; Negotiating; Neurotransmitter Agents
- From:Psychiatry Investigation 2014;11(4):476-480
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population. METHODS: Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale. RESULTS: SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale. CONCLUSION: We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population.
