Are Hypoechoic Lesions on Transrectal Ultrasonography a Marker for Clinically Significant Prostate Cancer?.
10.4111/kju.2013.54.10.666
- Author:
Tae Il NOH
1
;
Yoon Sun SHIN
;
Ji Sung SHIM
;
Jong Hyun YOON
;
Jae Heon KIM
;
Jae Hyun BAE
;
Du Geon MOON
;
Jae Young PARK
Author Information
1. Department of Urology, Korea University Ansan Hospital, Ansan, Korea. jaeyoungpark@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Clinical marker;
Prostate neoplasms;
Ultrasonography
- MeSH:
Biomarkers;
Biopsy;
Digital Rectal Examination;
Humans;
Logistic Models;
Passive Cutaneous Anaphylaxis;
Prostate;
Prostatic Neoplasms;
Retrospective Studies
- From:Korean Journal of Urology
2013;54(10):666-670
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the relationship of transrectal ultrasound (TRUS) findings with the pathological characteristics of prostate cancer (PCa). MATERIALS AND METHODS: The study was conducted retrospectively by analyzing the data for 970 patients who underwent prostate biopsies. Gleason scores and other clinical variables were compared between PCa patients with and without hypoechoic lesions on TRUS. RESULTS: Of the 970 patients, PCa was diagnosed in 291 (30%). Of these, high-grade PCa (Gleason score of 7 or more) was diagnosed in 190 (65%). The cancer detection rate was higher in patients with hypoechoic lesions (43.9%) than in those without hypoechoic lesions (21.4%, p<0.001). High-grade PCa was detected more often in patients with hypoechoic lesions than in those without hypoechoic lesions (p<0.001). Independent predictors for high-grade PCa by logistic regression analysis included hypoechoic lesions on TRUS and abnormal digital rectal examination findings. CONCLUSIONS: Patients with PCa who had hypoechoic lesions on TRUS had more aggressive pathological disease than did those without lesions. Therefore, hypoechoic lesions on TRUS could be a marker for clinically significant PCa.
