Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer.
10.3802/jgo.2012.23.3.175
- Author:
Stephen Chee Liang KOH
1
;
Chan Yiong HUAK
;
Delfi LUTAN
;
Johny MARPUANG
;
Suwiyoga KETUT
;
Nyoma Gede BUDIANA
;
Agustria Zainu SALEH
;
Mohamad Farid AZIZ
;
Hariyono WINARTO
;
Heru PRADJATMO
;
Nguyen Khac Han HOAN
;
Pham Viet THANH
;
Mahesh CHOOLANI
Author Information
1. Department of Obstetrics and Gynaecology, National University Health System (NUHS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore. obgmac@nus.edu.sg
- Publication Type:Original Article
- Keywords:
Age;
Epithelial ovarian cancer;
Tumor markers
- MeSH:
Asian Continental Ancestry Group;
Humans;
Neoplasms, Germ Cell and Embryonal;
Neoplasms, Glandular and Epithelial;
Ovarian Neoplasms;
ROC Curve;
Sensitivity and Specificity;
Tissue Kallikreins;
Biomarkers, Tumor
- From:Journal of Gynecologic Oncology
2012;23(3):175-181
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. METHODS: Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 specimens from patients presenting with ovarian tumors, which include 156 benign cysts, 172 epithelial ovarian cancers (stage I/II, n=72; stage III/IV, n=100), 36 germ cell tumors and 11 borderline tumors, were included in the study analysis. Receiver operating characteristic analysis were performed to determine the cutoffs for age, CA-125, hK6, and hK10. Sensitivity, specificity, negative, and positive predictive values were determined for various combinations of the biomarkers. RESULTS: The levels of hK6 and hK10 were significantly elevated in ovarian cancer cases compared to benign cysts. Combination of 3 markers, age/CA-125/hk6 or CA-125/hk6/hk10, showed improved specificity (100%) and positive predictive value (100%) for prediction of ovarian cancer, when compared to the performance of single markers having 80-92% specificity and 74-87% positive predictive value. Four-marker combination, age/CA-125/hK6/hK10 also showed 100% specificity and 100% positive predictive value, although it demonstrated low sensitivity (11.9%) and negative predictive value (52.8%). CONCLUSION: The combination of human tissue kallikreins and CA-125 showed potential for improving prediction of epithelial ovarian cancer in patients presenting with ovarian tumors.