Opportunistic lung infections as a manifestation of Good's syndrome.
10.4168/aard.2015.3.5.365
- Author:
Suk Yeon KIM
1
;
Joo Hee KIM
;
Ha Won HWANG
;
Kwang Youn KIM
;
Sunghoon PARK
;
Young Il HWANG
;
Seung Hun JANG
;
Ki Suck JUNG
Author Information
1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. luxjhee@gmail.com
- Publication Type:Case Report
- Keywords:
Good's syndrome;
Thymoma;
Hypogammaglobulinemia;
Pneumonia;
Opportunistic infections
- MeSH:
Agammaglobulinemia;
Autoimmune Diseases;
B-Lymphocytes;
Cytomegalovirus;
Ganciclovir;
Humans;
Immunoglobulins;
Immunoglobulins, Intravenous;
Lung*;
Opportunistic Infections;
Pneumocystis jirovecii;
Pneumonia;
Thymectomy;
Thymoma
- From:Allergy, Asthma & Respiratory Disease
2015;3(5):365-369
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Good's syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be managed by intravenous immunoglobulin (IVIG) replacement therapy. We describe 2 patients who presented with Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good's syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and they are all well without additional infections, receiving regular IVIG replacement.
