Iodinated contrast media-induced fixed drug eruption.
10.4168/aard.2015.3.5.375
- Author:
Jisu SHIM
1
;
Soojie CHUNG
;
Gun Woo KIM
;
Kyoung Hee SOHN
;
Ju Young KIM
;
Hye Ryun KANG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. helenmed@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Contrast media;
Drug eruptions;
Delayed hypersensitivity;
Intradermal tests
- MeSH:
Aged;
Carcinoma, Hepatocellular;
Contrast Media;
Drug Eruptions*;
Forearm;
Hand;
Humans;
Hypersensitivity;
Hypersensitivity, Delayed;
Intradermal Tests;
Iohexol;
Iopamidol;
Liver Cirrhosis;
Male
- From:Allergy, Asthma & Respiratory Disease
2015;3(5):375-379
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Iodinated contrast media (ICM) can cause not only immediate onset hypersensitivity but also delayed onset hypersensitivity. While the most common form of delayed onset hypersensitivity reaction to ICM is exanthematous eruption, fixed drug eruption (FDE) can occur rarely related to ICM. A 70-year-old male with liver cirrhosis and hepatocellular carcinoma repeatedly experienced erythematous patches on his right forearm and hand 6 hours after exposure to iopromide for computed tomography scan. ICM induced FDE was diagnosed clinically. Intradermal test with 6 kinds of ICM (iobitridol, iohexol, iomeprol, iopamidol, iopromide, and iodixanol) was performed and showed the weakest positive reaction to iohexol compared to the others in 48 hours. After changing iopromide to iohexol based on these results, FDE did not recur. We report here a case of iopromide induced FDE which was successfully prevented by changing ICM to iohexol based on intradermal test results.
