Transfusion-related acute lung injury; clinical perspectives.
10.4097/kjae.2015.68.2.101
- Author:
Jeongmin KIM
1
;
Sungwon NA
Author Information
1. Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. nswksj@yuhs.ac
- Publication Type:Review
- Keywords:
Acute lung injury;
Diagnosis;
Etiology;
Prevention and control;
Prognosis;
Transfusion reaction
- MeSH:
Acute Lung Injury*;
Blood Group Incompatibility;
Diagnosis;
Female;
Humans;
Mortality;
Plasma Volume;
Prognosis;
Tissue Donors
- From:Korean Journal of Anesthesiology
2015;68(2):101-105
- CountryRepublic of Korea
- Language:English
-
Abstract:
Transfusion-related acute lung injury (TRALI) was introduced in 1983 to describe a clinical syndrome seen within 6 h of a plasma-containing blood products transfusion. TRALI is a rare transfusion complication; however, the FDA has suggested that TRALI is the leading cause of transfusion-related mortality. Understanding the pathogenesis of TRALI will facilitate adopting preventive strategies, such as deferring high plasma volume female product donors. This review outlines the clinical features, pathogenesis, treatment, and prevention of TRALI.
