A Case of Endometrial Cancer with Hereditary Non-Polyposis Colorectal Cancer (HNPCC).
- Author:
Jae Hee YOON
1
;
Seon Kyung LEE
;
Suk Hee LEE
;
Seo Yun TONG
;
So Ra KIM
;
In Gu DO
;
Seung Bo KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Kyung Hee University, Seoul, Korea. andy2155@korea.com
- Publication Type:Case Report
- Keywords:
Endometrial cancer;
Hereditary non-polyposis colorectal cancer (HNPCC);
MSI (microsatellite instability);
MMR (mismatch repair) gene
- MeSH:
Colon;
Colonic Neoplasms;
Colorectal Neoplasms*;
Endometrial Neoplasms*;
Endometrium;
Female;
Humans
- From:Korean Journal of Obstetrics and Gynecology
2005;48(6):1555-1562
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Endometrial cancer is the most common malignant disorder that can be associated with hereditary non-polyposis colorectal cancer (HNPCC), which is known as Lynch II syndrome. HNPCC is a polyposis of the colon which is inherited in an autosomal dominant pattern and can cause cancer in other organs, especially in the endometrium. The overall risk of a women with HNPCC to develop endometrial cancer is 40-60%, much higher than the 3% of the general population of women. The average age of developing endometrial cancer of a women with HNPCC is 45 years of age and is often found before development of colon cancer. We have recently experienced a case of de novo type of hereditary non-polyposis colorectal cancer associated with endometrial cancer, hence we are reporting this case with a brief review of literatures.
