Predictors of Relapse in Patients with Organizing Pneumonia.
10.4046/trd.2015.78.3.190
- Author:
Minjung KIM
1
;
Seung Ick CHA
;
Hyewon SEO
;
Kyung Min SHIN
;
Jae Kwang LIM
;
Hyera KIM
;
Seung Soo YOO
;
Jaehee LEE
;
Shin Yup LEE
;
Chang Ho KIM
;
Jae Yong PARK
Author Information
1. Department of Internal Medicine Kyungpook National University School of Medicine, Daegu, Korea. sicha@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Cryptogenic Organizing Pneumonia;
Recurrence;
Vital Capacity
- MeSH:
Cryptogenic Organizing Pneumonia;
Follow-Up Studies;
Humans;
Methods;
Multivariate Analysis;
Pneumonia*;
Recurrence*;
Retrospective Studies;
Tertiary Care Centers;
Vital Capacity
- From:Tuberculosis and Respiratory Diseases
2015;78(3):190-195
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. METHODS: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). RESULTS: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), PaO2/FiO2, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively). CONCLUSION: This study shows that FVC, PaO2/FiO2 and serum protein level at presentation can significantly predict relapse in OP patients.
