Hepatitis E as a trigger for acute-on-chronic liver failure
- Author:
Maria BUTI
1
;
Juan Carlos RUIZ-COBO
;
Rafael ESTEBAN
;
Mar RIVEIRO-BARCIELA
Author Information
- Publication Type:Review
- From:Clinical and Molecular Hepatology 2025;31(Suppl):S196-S204
- CountryRepublic of Korea
- Language:English
- Abstract: Acute hepatitis E virus (HEV) infection is typically self-limiting and has a favourable prognosis. However, certain populations such as patients with pre-existing chronic liver disease may experience severe manifestations, including progression to acute-on-chronic liver failure (ACLF). Among viral hepatitis types, hepatitis A, E, and B are major causes of ACLF. Active screening and early diagnosis of HEV infection in patients with cirrhosis, especially those who develop ACLF, can improve management and enable timely antiviral therapy. Preventive measures, including HEV vaccination for high-risk groups, could reduce the morbidity and mortality associated with hepatitis E.
