Experimental Mouse Models and Human Lung Organoid Models for Studying Chronic Obstructive Pulmonary Disease
10.4062/biomolther.2024.148
- Author:
Young Ae JOE
1
;
Min Ju LEE
;
Hong Seok CHOI
Author Information
1. Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
- Publication Type:Review
- From:Biomolecules & Therapeutics
2024;32(6):685-696
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality throughout the world, is a highly complicated disease that includes chronic airway inflammation, airway remodeling, emphysema, and mucus hypersecretion.For respiratory function, an intact lung structure is required for efficient air flow through conducting airways and gas exchange in alveoli. Structural changes in small airways and inflammation are major features of COPD. At present, mechanisms involved in the genesis and development of COPD are poorly understood. Currently, there are no effective treatments for COPD. To develop better treatment strategies, it is necessary to study mechanisms of COPD using proper experimental models that can recapitulate distinctive features of human COPD. Therefore, this review will discuss representative established mouse models to investigate inflammatory processes and basic mechanisms of COPD. In addition, human COPD-mimicking human lung organoid models are introduced to help researchers overcome limits of mouse COPD models.
