Triglyceride-glucose index predicts future metabolic syndrome in an adult population, Korea:a prospective cohort study
10.15747/ACNM.2024.16.3.168
- Author:
Min-Su PARK
1
Author Information
1. Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Korea
- Publication Type:Original article
- From:
Annals of Clinical Nutrition and Metabolism
2024;16(3):168-172
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:The triglyceride-glucose (TyG) index has been proposed as a reliable surrogate marker for insulin resistance.This study aimed to assess the utility of the TyG index in predicting the future presence of metabolic syndrome (MetS) in an adult population.
Methods:A total of 3,241 adults aged 40–70 years were included in this cross-sectional study. MetS was diagnosed based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria, which requires the presence of at least three of the following components: abdominal obesity, elevated blood pressure, dysglycemia, hypertriglyceridemia, and low high-density lipoprotein cholesterol.
Results:In comparison to the homeostasis model assessment of insulin resistance (HOMA-IR), the TyG index exhibited superior diagnostic performance, with a higher area under the receiver operating characteristic curve of 0.854 vs. 0.702 for HOMA-IR. The 95% confidence interval for the TyG index was narrower, reflecting a more consistent predictive ability. Sensitivity for the TyG index was 79.7%, while specificity was 79.3%, compared to HOMA-IR, which showed a sensitivity of 52.7% and specificity of 78.3%.
Conclusion:The TyG index is a highly effective and robust tool for identifying individuals at risk for MetS, demonstrating superior sensitivity and predictive accuracy over HOMA-IR. This index could be a valuable clinical marker for early detection of MetS, aiding in the prevention and management of associated metabolic disorders.
