Effect of Parathyroid Hormone on Left Ventricular Hypertrophy in Aged Ovariectomized Rats.
10.4070/kcj.1998.28.6.953
- Author:
Chang Gyu PARK
;
Dong Joo OH
;
Hong Seog SEO
;
Chang Sub YHM
;
Han Geam KIM
;
Eung Joo KIM
;
Eun Mi LEE
;
Jung Chun AHN
;
Woo Heuk SONG
;
Do Sun YIM
;
Young Hoon KIM
;
Wan Joo SHIM
;
Young Moo RO
- Publication Type:In Vitro ; Original Article
- Keywords:
Parathyroid hormone;
Left ventricular hypertrophy;
Ovariectomy
- MeSH:
Adult;
Animals;
Estrogens;
Female;
Fibrosis;
Heart;
Humans;
Hyperparathyroidism, Primary;
Hypertrophy;
Hypertrophy, Left Ventricular*;
Incidence;
Kidney;
Myocytes, Cardiac;
Ovariectomy;
Parathyroid Hormone*;
Rats*;
Rats, Sprague-Dawley
- From:Korean Circulation Journal
1998;28(6):953-960
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It has been well known that the bone and kidney are the principle organs of parathyroid hormine (PTH) actions. Although patients with primary hyperparathyroidism show a high incidence of LVH and trophic effects of PTH on adult rat ventricular cardiomyocytes were investigated in vitro, effect of PTH on the cardiac tissue in vivo is unknown. METHODS: We examined the effects of PTH on the cardiomyocyte and interstitial tissue using adult rat heart. Twenty-two female Sprague-Dawley rats were ovariectomized bilaterally at three months old and weighing in 250 - 300 gm in order to exclude the trophic effect of estrogen. We administrated human parathyroid hormone (20 ug subcutaneously 5 times per week) to 12 rats for 4 weeks after raising for 8 weeks (PTH group):the remaining 10 rats received only normal saline (control). We measured left ventricular thickness [IVS+LVPW)/2] and number of cardiomyocytes and interstitial fibrosis on LM (H & E and Masson's trochrome stain) and EM. RESULTS: 1) LV wall thickeness tended to increase in PTH group as compared with control (2.16+/-0.31 vs 1.12+/-0.21 mm, p=0.099). 2) The number of cardiomyocyte in PTH group was significantly less than that of control (61.2+/-13.1 vs 70.5+/-14.9, p=0.003, Magnification x 400). 3) There was no significant change of interstitial fibrosis between PTH group and control. CONCLUSION: These results shggest that PTH may produce left ventricular hypertrophic effects in aged ovariectomized rat that resulted form hypertrophy of cardiomyocyte without increase of interstitial connetive tissue.
