Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of cAMP.
10.4097/kjae.2010.58.4.374
- Author:
Chul Ho CHANG
1
;
Go Un ROH
;
Wyun Kon PARK
Author Information
1. Department of Anesthesiology and Pain Medicine, and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea. wkp7ark@yuhs.ac
- Publication Type:Original Article
- Keywords:
beta-adrenoceptor;
cAMP;
G-protein;
Propofol
- MeSH:
Adenosine;
Animals;
Forskolin;
GTP-Binding Proteins;
Guanosine 5'-O-(3-Thiotriphosphate);
Guinea Pigs;
Isoproterenol;
Myocardium;
Propofol;
Signal Transduction
- From:Korean Journal of Anesthesiology
2010;58(4):374-377
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate). METHODS: The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades. RESULTS: While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 micrometer) did not alter the levels of cAMP. CONCLUSIONS: Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardium.
