A Rare Case of Isolated Central Nervous System Neoplasm With Histiocytic Features
- Author:
Yoonsoo CHOI
1
;
Yujin LEE
;
Young Il KIM
;
Seung Ho YANG
Author Information
- Publication Type:CASE REPORT
- From:Dementia and Neurocognitive Disorders 2025;24(1):23-28
- CountryRepublic of Korea
- Language:English
- Abstract: This paper discusses a rare case of a 49-year-old female diagnosed with a central nervous systemisolated neoplasm with histiocytic features, classified as histiocytic neoplasm, not otherwise specified (NOS). Despite comprehensive histopathological and genetic studies, accurately diagnosing the case proved challenging. Initial surgical findings and frozen biopsy suggested a low-grade glioma; however, subsequent immunohistochemistry and genetic analysis excluded known histiocytic subtypes such as ALK-positive histiocytosis and Erdheim-Chester disease. The patient’s condition improved following occupational rehabilitation therapy for right upper motor weakness, as well as anticonvulsant and radiation therapy, and her neurological condition remains stable. This case underscores the diagnostic challenges of Histiocytic Neoplasms and the necessity for interdisciplinary collaboration and sophisticated diagnostic techniques.
