Comprehensive Clinical and Behavioral Characteristics of Mild Cognitive Impairment According to Amyloid Positivity: A Large Multi-Center Korean Cohort
10.12779/dnd.2025.24.2.102
- Author:
Seung Ae KIM
1
;
Yeshin KIM
;
Duk L. NA
;
Sang Won SEO
;
Hyemin JANG
;
Author Information
1. Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
- Publication Type:Original Article
- From:Dementia and Neurocognitive Disorders
2025;24(2):102-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:and Purpose: Mild cognitive impairment (MCI) is a transitional stage to dementia, Alzheimer’s disease being a major cause. Although amyloid beta-positive (Aβ+) MCI has been well-characterized, Aβ-negative (Aβ−) MCI has not. This study compared the comprehensive clinical and behavioral characteristics of Aβ+ and Aβ− MCI in a large multicenter cohort to better understand the heterogeneity of MCI, and to identify contributing factors to cognitive impairment.
Methods:A total of 686 MCI participants were included. Aβ positivity was determined using Aβ positron emission tomography imaging with a direct conversion Centiloid cutoff value of 25.5. Standardized assessment and questionnaires were used to collect a wide range of clinical information, including vascular risk factors, cognition, daily living function, neuropsychiatric symptoms, and lifestyle behavior. Groups were compared using independent t-tests and χ2 tests.
Results:Aβ+ participants (n=406) were older, predominantly female, and more likely to be ApoE4 carriers. In contrast, Aβ− participants (n=280) showed higher vascular risk factors, including diabetes, elevated body mass index, and higher C-reactive protein levels.Aβ+ participants exhibited worse global cognition and functional decline, with a higher prevalence of delusions and appetite disturbances. Meanwhile, Aβ− participants reported greater social engagement, but poorer sleep quality.
Conclusions:This study highlights the distinct clinical and lifestyle profiles of Aβ+ and Aβ− MCI, illuminating the heterogeneity of MCI and its underlying factors in the Korean population.
