Managing Parahemophilia: A Rare Coagulation Disorder – Case Report and Review
10.15264/cpho.2025.32.1.29
- Author:
Sanghamitra RAY
1
;
Nidhi CHOPRA
;
Sumit MEHNDIRATTA
;
Prashant PRABHAKAR
;
Amitabh SINGH
Author Information
1. Department of Paediatrics, Vardhman Mahavir Medical College & Safdarjung Medical College, Delhi, India
- Publication Type:CASE REPORT
- From:Clinical Pediatric Hematology-Oncology
2025;32(1):29-32
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 5-month-old male child was admitted with cough and fever, during which excessive bleeding occurred from a venipuncture site. Born from a third-degree consanguineous marriage, the child was developmentally normal. Routine blood tests showed a slightly elevated white blood cell count due to infection, while coagulation studies revealed prolonged PT and APTT. A mixing study indicated no inhibitors.Advanced testing showed normal levels of fibrinogen and factor VIII, but a significantly low factor V level (2.2%), indicating moderate factor V deficiency. The child received fresh frozen plasma (FFP) transfusions as needed and has been thriving with regular follow-ups. Genetic counseling was provided to the parents, who also had abnormal coagulation profiles but no bleeding tendencies. Genetic testing was offered but not pursued due to financial constraints. This case highlights the importance of awareness of inherited bleeding disorders in consanguineous families and the need for supportive management and counseling.
