Clinical Manifestations of Ocular Syphilis Combined with Neurosyphilis.
10.3341/jkos.2014.55.4.602
- Author:
Yong Wun CHO
1
;
Che Ron KIM
;
Yong Seop HAN
;
In Young CHUNG
;
Jong Moon PARK
Author Information
1. Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. parkjm@gnu.ac.kr
- Publication Type:Original Article
- Keywords:
CSF analysis;
Neurosyphilis;
Ocular syphilis
- MeSH:
Cerebrospinal Fluid;
Early Diagnosis;
Fluorescein Angiography;
Fluorescent Treponemal Antibody-Absorption Test;
Hemagglutination;
Humans;
Male;
Neurosyphilis*;
Papilledema;
Retinaldehyde;
Retrospective Studies;
Serologic Tests;
Sexually Transmitted Diseases;
Syphilis*;
Treponema pallidum;
Uveitis
- From:Journal of the Korean Ophthalmological Society
2014;55(4):602-607
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report the manifestation of ocular syphilis combined with neurosyphilis in patients who present with uveitis clinically and are diagnosed initially by an ophthalmologist. METHODS: This study is a retrospective, clinical investigation of seven male patients with ocular syphilis from a single tertiary center between 2009 and 2012. RESULTS: The average age of the patients at onset was 44.4 years (range, 33-71 years). Posterior segment involvement was found in all patients. Two patients had papillitis. In serologic testing, all patients had positive responses to Venereal Disease Research Laboratory (VDRL), fluorescent treponemal antibody-absorption test (FTA-ABS) and Treponema pallidum hemagglutination (TPHA). In fluorescein angiography (FAG), retinal vascular and disc leakage was the most common finding. Cerebrospinal fluid (CSF) analysis was performed for six patients and demonstrated positive CSF FTA-ABS and CSF TPHA tests in all patients. CSF VDRL was reactive in 2 patients (33.3%). CONCLUSIONS: All patients with ocular syphilis were diagnosed with neurosyphilis based on the analysis of CSF with FTA-ABS and TPHA. Ophthalmologists play an important role in the early diagnosis and treatment of syphilis.
