Hepatic Lesions that Mimic Metastasis on Radiological Imaging during Chemotherapy for Gastrointestinal Malignancy: Recent Updates.
10.3348/kjr.2017.18.3.413
- Author:
Sung Hye YOU
1
;
Beom Jin PARK
;
Yeul Hong KIM
Author Information
1. Department of Radiology, Anam Hospital, Korea University College of Medicine, Seoul 02841, Korea. radiolbj226@gmail.com
- Publication Type:Review
- Keywords:
Chemotherapy-induced focal hepatopathy;
Steatosis;
Steatohepatitis;
Oxaliplatin;
Sinusoidal obstructive syndrome;
Peliosis
- MeSH:
Abscess;
Diagnosis;
Drug Therapy*;
Eosinophils;
Fatty Liver;
Humans;
Liver;
Neoplasm Metastasis*;
Therapeutic Uses
- From:Korean Journal of Radiology
2017;18(3):413-426
- CountryRepublic of Korea
- Language:English
-
Abstract:
During chemotherapy in patients with gastrointestinal malignancy, the hepatic lesions may occur as chemotherapy-induced lesions or tumor-associated lesions, with exceptions for infectious conditions and other incidentalomas. Focal hepatic lesions arising from chemotherapy-induced hepatopathies (such as chemotherapy-induced sinusoidal injury and steatosis) and tumor-associated eosinophilic abscess should be considered a mimicker of metastasis in patients with gastrointestinal malignancy. Accumulating evidence suggests that chemotherapy for gastrointestinal malignancy in the liver has roles in both the therapeutic effects for hepatic metastasis and injury to the non-tumor bearing hepatic parenchyma. In this article, we reviewed the updated concept of chemotherapy-induced hepatopathies and tumor-associated eosinophilic abscess in the liver, focusing on the pathological and radiological findings. Awareness of the causative chemo-agent, pathophysiology, and characteristic imaging findings of these mimickers is critical for accurate diagnosis and avoidance of unnecessary exposure of the patient to invasive tissue-based diagnosis and operations.
