Quantitative Measurement of Hepatic Fibrosis with Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients with Chronic Hepatitis B Infection: A Comparative Study on Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis-4 Index.
10.3348/kjr.2017.18.3.444
- Author:
Guy Mok LEE
1
;
Youe Ree KIM
;
Jong Hyun RYU
;
Tae Hoon KIM
;
Eun Young CHO
;
Young Hwan LEE
;
Kwon Ha YOON
Author Information
1. Department of Radiology, Wonkwang University School of Medicine, Iksan 54538, Korea. khy1646@wku.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
Liver;
Magnetic resonance imaging;
Chronic hepatitis B;
Fibrosis;
Gadoxetic acid;
Gd-EOB-DTPA
- MeSH:
Aspartate Aminotransferases*;
Aspartic Acid*;
Blood Platelets*;
Fibrosis*;
Hepatitis B, Chronic*;
Hepatitis, Chronic*;
Humans;
Liver;
Magnetic Resonance Imaging*;
ROC Curve
- From:Korean Journal of Radiology
2017;18(3):444-451
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To quantitatively measure hepatic fibrosis on gadoxetic acid-enhanced magnetic resonance (MR) in chronic hepatitis B (CHB) patients and identify the correlations with aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) values. MATERIALS AND METHODS: This study on gadoxetic acid-enhanced 3T MR imaging included 81 patients with CHB infection. To quantitatively measure hepatic fibrosis, MR images were analyzed with an aim to identify inhomogeneous signal intensities calculated from a coefficient of variation (CV) map in the liver parenchyma. We also carried out a comparative analysis between APRI and FIB-4 based on metaregression results. The diagnostic performance of the CV map was evaluated using a receiver-operating characteristic (ROC) curve. RESULTS: In the MR images, the mean CV values in control, groups I, II, and III based on APRI were 4.08 ± 0.92, 4.24 ± 0.80, 5.64 ± 1.11, and 5.73 ± 1.28, respectively (p < 0.001). In CHB patients grouped by FIB-4, the mean CV values of groups A, B, and C were 4.22 ± 0.95, 5.40 ± 1.19, and 5.71 ± 1.17, respectively (p < 0.001). The mean CV values correlated well with APRI (r = 0.392, p < 0.001) and FIB-4 (r = 0.294, p < 0.001). In significant fibrosis group, ROC curve analysis yielded an area under the curve of 0.875 using APRI and 0.831 using FIB-4 in HB, respectively. CONCLUSION: Gadoxetic acid-enhanced MR imaging for calculating a CV map showed moderate correlation with APRI and FIB-4 values and could be employed to quantitatively measure hepatic fibrosis in patients with CHB.
