Nitric Oxide Synthesis in the Adult and Developing Kidney.
- Author:
Ki Hwan HAN
1
;
Ju Young JUNG
;
Ku Yong CHUNG
;
Hyang KIM
;
Jin KIM
Author Information
- Publication Type:Original Article
- Keywords: Kidney; Development; Renal hemodynamics; Nitric oxide
- MeSH: Adult*; Capillaries; Endothelial Cells; Epithelial Cells; Hemodynamics; Humans; Kidney*; Neurons; Nitric Oxide Synthase; Nitric Oxide*; Protein Isoforms
- From:Electrolytes & Blood Pressure 2006;4(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: Nitric oxide (NO) is synthesized within the adult and developing kidney and plays a critical role in the regulation of renal hemodynamics and tubule function. In the adult kidney, the regulation of NO synthesis is very cell type specific and subject to distinct control mechanisms of NO synthase (NOS) isoforms. Endothelial NOS (eNOS) is expressed in the endothelial cells of glomeruli, peritubular capillaries, and vascular bundles. Neuronal NOS (nNOS) is expressed in the tubular epithelial cells of the macula densa and inner medullary collecting duct. Furthermore, in the immature kidney, the expression of eNOS and nNOS shows unique patterns distinct from that is observed in the adult. This review will summarize the localization and presumable function of NOS isoforms in the adult and developing kidney.
