Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins.
- Author:
Woon Kyu LEE
1
;
Sun Mi JUNG
;
Jin Oh KWAK
;
Seok Ho CHA
Author Information
- Publication Type:Original Article
- Keywords: Kidney; Organic anion; Multispecific organic anion transporter; Tubular secretion; Xenobiotics; Renal localization; Caveolin
- MeSH: Body Fluids; Caveolae; Caveolins*; Gene Expression; Homeostasis; Humans; Kidney; Multidrug Resistance-Associated Proteins; Organic Anion Transporters*; Protein Isoforms; Protein Kinase C; Xenobiotics
- From:Electrolytes & Blood Pressure 2006;4(1):8-17
- CountryRepublic of Korea
- Language:English
- Abstract: The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds. Among these renal functions, excretion/reabsorption of endogenous and exogenous substance is very important for the maintenance of physiological homeostasis in the body. Recently discovered organic anion transporters (OAT or SLC22A) have important roles for renal functions. It is well known as drug transporter. Several isoforms belong to SLC22A family. They showed different transport substrate spectrums and different localizations within the kidney. Their gene expressions are changed by some stimulus. The functional transport properties are regulated by protein kinase C. In addition, the function of organic anion transporters are also regulated by protein-protein interaction, such as caveolin which is compositional protein of caveolae structure. In this review, we will give an introduction of organic anion transporters and its regulatory mechanisms.
