Plasma Level of IL-6 and Its Relationship to Procoagulant and Fibrinolytic Markers in Acute Ischemic Stroke.
10.3349/ymj.2006.47.2.201
- Author:
Jae Woo SONG
1
;
Kyung Soon SONG
;
Jong Rak CHOI
;
Shin Young KIM
;
Ji Hyuk RHEE
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. cjr0606@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Stroke;
cytokine;
procoagulant;
fibrinolysis
- MeSH:
Thrombosis;
Thrombolytic Therapy;
Thrombin/chemistry;
Plasminogen Activator Inhibitor 1/blood;
Phospholipids/chemistry;
Models, Statistical;
Middle Aged;
Male;
Ischemia/*blood/*pathology;
Interleukin-6/*blood/metabolism;
Humans;
Hemostasis;
*Fibrinolysis;
Female;
Enzyme-Linked Immunosorbent Assay;
Cytokines/metabolism;
Coagulants/*metabolism;
Cerebrovascular Accident/*blood/*pathology;
Blood Coagulation Factors/metabolism;
Antithrombins/chemistry;
Aged;
Acute Disease
- From:Yonsei Medical Journal
2006;47(2):201-206
- CountryRepublic of Korea
- Language:English
-
Abstract:
Procoagulant or impaired fibrinolytic states as well as inflammatory reactions mediated by cytokines are likely involved in the pathogenesis of acute ischemic stroke. We examined the potential relationship between interleukin 6 (IL-6) and hemostatic markers. The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex (TAT), and plasminogen-antiplasmin complex (PAP). Circulating IL-6 levels were measured using ELISA (Quantikine, R and D systems, MN, USA). Circulating IL-6 (mean, 26.5 pg/mL) and PAI-1 (mean, 19.9 ng/mL) levels were higher in patients with acute stroke than in healthy subjects (mean, 3.0 pg/mL, 10.4 ng/mL, respectively). TAT levels were statistically different according to the etiologic subtypes of stroke (atherogenic, 2.5 ng/mL; lacunar 3.2 ng/mL; cardiogenic 9.9 ng/mL, p = 0.021). Neither procoagulant levels nor fibrinolytic markers significantly correlated with circulating IL-6 levels. Our findings suggest that elevated proinflammatory cytokines during the initial hours of ischemic stroke may be an independent pathogenic factor or a consequence of the thrombotic event with no relationship to the procoagulant or fibrinolytic states.
