Agranulocytosis Induced by Vancomycin in an ESRD Patient on CAPD.
- Author:
Young Il JO
1
;
Jae Ho YOON
;
Sang Youl SHIN
;
Won Chul CHANG
;
Byung Kook KIM
;
Choon Jo JIN
;
Jong Oh SONG
Author Information
1. Division of Nephrology, Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea. josong@kku.ac.kr
- Publication Type:Case Report
- Keywords:
Agranulocytosis;
Vancomycin;
Peritoneal Dialysis;
Continuous Ambulatory
- MeSH:
Aged;
Agranulocytosis/*chemically induced/drug therapy;
Anti-Bacterial Agents/*adverse effects/therapeutic use;
Catheters, Indwelling/microbiology;
Granulocyte Colony-Stimulating Factor/therapeutic use;
Human;
Kidney Failure, Chronic/complications/therapy;
Male;
Peritoneal Dialysis, Continuous Ambulatory;
Staphylococcal Infections/drug therapy;
Vancomycin/*adverse effects/therapeutic use
- From:The Korean Journal of Internal Medicine
2004;19(1):58-61
- CountryRepublic of Korea
- Language:English
-
Abstract:
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA) -associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
