A Case of Lactic Acidosis Caused by Stavudine in an AIDS Patient.
- Author:
Byoung Chul CHO
1
;
Sang Hoon HAN
;
Suk Hoon CHOI
;
Jun Yong CHOI
;
Kyung Hee CHANG
;
Young Goo SONG
;
June Myung KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. jmkim@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Lactic acidosis;
Stavudine;
HIV;
Anti-HIV Drugs;
Acquired Immunodeficiency Syndrome
- MeSH:
Acidosis, Lactic/*chemically induced;
Acquired Immunodeficiency Syndrome/*drug therapy;
Adult;
Anti-HIV Agents/*adverse effects/therapeutic use;
Female;
Human;
Sodium Bicarbonate/therapeutic use;
Stavudine/*adverse effects/therapeutic use
- From:The Korean Journal of Internal Medicine
2004;19(1):66-69
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nucleoside reverse transcriptase inhibitors (NRTIs), which are used for the treatment of human immunodeficiency virus (HIV) infection have been associated with a wide spectrum of clinical manifestations, including hepatic steatosis, lipodystrophy, myopathy, and lactic acidosis. Such adverse effects are postulated to result from the inhibition of mitochondrial DNA gamma polymerase, which causes the depletion of mitochondrial DNA and eventual the disruption of oxidative phosphorylation. Although cases of severe decompensated lactic acidosis are rare, this syndrome is associated with a high mortality rate. We report upon the first Korean case, of severe lactic acidosis in an acquired immunodeficiency syndrome (AIDS) patient receiving stavudine, an anti-HIV drug.
