Susceptibility of experimental animals to reinfection with Clonorchis sinensis.
10.3347/kjp.2006.44.2.163
- Author:
Woon Mok SOHN
1
;
Hongman ZHANG
;
Min Ho CHOI
;
Sung Tae HONG
Author Information
1. Department of Parasitology and Institute of Health Sciences, Gyeongsan National University College of Medicine, Jinju 660-751, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Clonorchis sinensis;
liver fluke;
reinfection;
resistance;
rats;
mice
- MeSH:
Rats;
Rabbits;
Praziquantel/therapeutic use;
Mice;
Guinea Pigs;
Dogs;
Cricetinae;
Clonorchis sinensis/immunology/*physiology;
Clonorchiasis/drug therapy/immunology;
Anthelmintics/therapeutic use;
Animals, Laboratory/immunology/*parasitology;
Animals
- From:The Korean Journal of Parasitology
2006;44(2):163-166
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study observed the resistance to reinfection with Clonorchis sinensis in various experimental animals including mice, guinea pigs, rabbits, and dogs, as well as rats and hamsters. The resistance rates to reinfection in rats, mice, hamsters, guinea pigs, rabbits, and dogs were 79.7%, 58.0%, -12.6%, 54.8%, 62.6%, and 6.0%, respectively. Worms recovered from reinfected rats and mice were immature, and significantly smaller than those from the primarily infected (P < 0.01), whereas those from other animals were fully matured to adults. These findings indicate that the protective response against reinfection with C. sinensis is prominent in rats and mice, and that they may be a good animal model to investigate the mechanism of resistance to reinfection with C. sinensis.
