A Case of Cerebral Infarction in a Child with Acute Lymphoblastic Leukemia Developed during Chemotherapy with E coli Asparaginase.
- Author:
Ji Hyun OH
1
;
Hyun Sang CHO
;
Sang Wook HAN
;
Chong Young PARK
Author Information
1. Department of Pediatrics, School of Medicine, Hallym University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
L-asparaginase;
Cerebral infarction;
Acute lymphoblastic leukemia
- MeSH:
Antithrombin III;
Asparaginase*;
Cerebral Infarction*;
Child*;
Drug Therapy*;
Escherichia coli*;
Factor IX;
Fibrinogen;
Head;
Humans;
Infarction;
Magnetic Resonance Imaging;
Plasminogen;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Protein C;
Protein S;
Seizures
- From:Korean Journal of Pediatric Hematology-Oncology
2000;7(2):305-309
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
E. coli L-asparaginase treatment during induction therapy in acute lymphoblastic leukemia is known to be rarely complicated by thromboembolic events. It causes deficiencies of antithrombin III, plasminogen, fibrinogen, factor IX, XI, protein C and protein S. We recently experienced a case of infarction during induction therapy in a 9-year-old child diagnosed with ALL. After the four dose of L-asparaginase, she had a generalized tonic- clonic seizure and MRI of the head showed both occipital infarction. She had gross recovery of the neurological impairment in 4 days. We report this case with brief review of literature.
