The Usefulness of Gestation Corrected Hy peruricemia as Predictors of the Recurrence of Preeclampsia and Obstetric Outcomes on Subsequent Pregnancy: A Single Center Retrospective Study in South Korea
10.14734/PN.2024.35.4.128
- Author:
Hee Young BANG
1
;
Jong Woon KIM
;
Yoon Ha KIM
;
Myeong Gyun CHOI
;
Tae Young KIM
;
Tae Ho PARK
Author Information
1. Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea
- Publication Type:Original article
- From:
Perinatology
2024;35(4):128-133
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:Hyperuricemia has been described commonly in preeclamptic pregnancies, often prece ding the diagnosis of preeclampsia and historically was used as a diagnostic marker of preeclampsia.The aim of this study was to determine the usefulness of gestation corrected hyperuricemia (GCH) to predict the recurrence of preeclampsia on subsequent pregnancy.
Methods:The retrospective study of 64 women who had previous preeclampsia and checked serum uric acid was analyzed. GCH was defined as being one standard deviation above the gestation-specific mean. And we used uric acid z-scores ([serum uric acid value-gestation specific mean]/standard deviation of the population) to account for gestation-specific alterations in uric acid and tested this as a continuous variable. The relationship between GCH and recurrence of preeclampsia on subsequent pregnancy was analyzed. Obstetric outcomes were reviewed according to absence or presence of GCH. P<0.05 was considered as significant.
Results:Of 64 women, seventeen had the development of recurrent preeclampsia (26.6%). The absence or presence of GCH was not associated with the recurrence of preeclampsia on subsequent pregnancy (P=0.267). And gestation-specific uric acid z-score as a continuous variable did not show any association with the prediction of preeclampsia on subsequent pregnancy (P=0.427). GCH was associated with the small for gestational age (P=0.010).
Conclusion:GCH does not predict the recurrence of preeclampsia on subsequent pregnancy.
